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Postdoctoral Fellowship, Translational Pharmacokinetic-Pharmacodynamic (PK-PD) modeling

City: Ottawa

Organizational Unit: Human Health Therapeutics 

Classification: RO 

Tenure: Term 

Duration: 2 Years

Language Requirements: English 

The NRC Advantage

Great Minds. One Goal. Canada's Success.


The National Research Council of Canada (NRC) is the Government of Canada's largest research organization supporting industrial innovation, the advancement of knowledge and technology development. We collaborate with over 70 colleges, universities and hospitals annually, work with 800 companies on their projects, and provide advice or funding to over 8000 Small and Medium-sized Enterprises (SMEs) each year.


We bring together the brightest minds to deliver tangible impacts on the lives of Canadians and people around the world. And now, we want to partner with you.  Let your expertise and inspirations make an impact by joining the NRC.


At NRC, we know diversity enables excellence in research and innovation. We are committed to a diverse and representative workforce, an open and inclusive work environment, and contributing to a more inclusive Canadian innovation system. 


NRC welcomes all qualified applicants and encourages candidates to self-declare as members of the following designated employment equity groups: women, visible minorities, Aboriginal peoples and persons with disabilities.


Please advise of any accommodation measures required to enable you to be assessed in a fair and equitable manner. They are available to all candidates for further assessment. Related information received will be addressed confidentially.

The Program

The NRC’s Postdoctoral Fellowship program offers PDFs access to unique world-class facilities and the opportunity to work alongside multi-disciplinary teams of expert researchers and technicians on projects of critical importance to Canada. PDFs will carry out research on innovative research projects, with opportunities for career development (publications and/or industry interaction).


PDFs will be offered appointments to the staff of the National Research Council on a term basis and will be offered salaries and benefits currently available to Research Officers. Salaries commensurate with experience are taxable and subject to other deductions. As a guide, the current annual PhD recruiting rate is $73,133. In addition PDFs will be allocated a travel fund to support their work.

Project Title

Shortwave infrared (SWIR) optical imaging: Novel applications in pharmacokinetic modeling of biotherapeutics

Preclinical pharmacokinetic (PK) studies support the prediction of drug efficacy and toxicity, selection of drug candidates and design of clinical trials. However, conventional PK studies rely on repeated blood and tissue sampling from a large number of animals combined with complex bioanalytical methods to determine drug concentrations.

The main objective of this proposal is to develop a novel image-guided PK platform that harnesses the unparalleled sensitivity, resolution, and tissue depth penetration of the shortwave infrared (SWIR) optical imaging instrumentation, recently developed by the Canadian company Photon etc in collaboration with NRC. This technology will be applied to quantitatively and non-invasively evaluate drug concentrations in mouse vascular and tissue compartments. The datasets generated will be used to feed into and validate the NRC’s PK modeling and simulation toolkit.

Your Challenge

NRC-HHT is seeking a PDF candidate who will provide strategic and technical expertise in the design and implementation of SWIR imaging methods for preclinical PK studies. The candidate will work collaboratively with internal/external research teams to integrate and support the application of SWIR imaging towards the discovery and development of next generation biotherapeutics.


Ph.D. degree or equivalent in Biomedical Imaging, Medical Biophysics, Pharmacy/Pharmacology, Biological Sciences or a related field.


For information on certificates and diplomas issued abroad, please see Degree equivalency


Experience in one (or more) of the following areas:

  • In vivo/ex vivo near infrared fluorescence imaging
  • Quantitative analysis of fluorescence optical images
  • Pharmacology of biologics
  • Pharmacokinetic analyses and modeling
  • Animal handling and experimentation is an asset

Condition of Employment

Reliability Status

Who is eligible?

  • Fellowships will be for two years contingent on satisfactory progress achieved during the first year.
  • Candidates should have obtained a PhD (or equivalent) within the past three years (PhD received on or after July 1, 2018) or expect to complete their PhD within 6 months of appointment.
  • Fellows will work in a lab under the direct supervision of an NRC researcher.

Application Requirements

In order to be considered for the program please include the following in your application, please note that you will need to attach the required documents as per the list below when submitting your application. Failure to do so will result in your application being excluded from searches.


  • Resume
  • Statement of Interest in the project (maximum one page in length)
  • PhD Transcript - an electronic copy is sufficient, it does not have to be an official version.
  • List of Publications


When submitting your application you can include the required documents in any attachment field such as «Second language evaluation results» or «Other attachments»


In addition, applicants who best meet the requirements of the position will be asked to provide three letters of recommendation at a later stage of the competition process.


Relocation assistance will be determined in accordance with the NRC's directives.

Salary Range

From $56,374 to $159,364 per annum. 


The Postdoctoral Fellowships Program is unique to the NRC. It falls under the RO/RCO classification system which uses a person-based classification system instead of the more common duties-based classification system. Candidates are remunerated based on their expertise, skill, outcomes and impacts of their previous work experience.


  • NRC employees enjoy a wide-range of benefits including comprehensive health and dental plans, pension and insurance plans, vacation and other leave entitlements.
  • Fellowships are open to nationals of all countries, although preference will be given to Canadian Citizens and Permanent Residents of Canada. Please include citizenship information in your application.
  • The incumbent must adhere to safe workplace practices at all times.
  • We thank all those who apply, however only those selected for further consideration will be contacted.



Please direct your questions, with the requisition number (11491) to:


Telephone: 613-299-4639

Closing Date: 19 March 2021 - 23:59 Eastern Time



For more information on career tools and other resources, check out Career tools and resources


*If you are currently a term or continuing employee at NRC, please apply through the SuccessFactors Careers module from your NRC computer.


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